In his different art periods, his work ranges from (i) nature, posed as a colonial remnant (Hotel América), (ii) the construction of local identity based on the notion of paradise (Flowers and later Abstractions), and (iii) the inquiry about the love/ hate relationship between the United States and what its physical proximity and axis of influence entail (Americana and Melting).

Del Paso relies on different techniques such as drawing, printmaking, sculpture, ceramics, video, and installation to achieve his artistic vision. He also has a short work on set design and literary work, in addition to articles and essays on the art.